Massy Tadjedin’s romantic drama “Last Night,” starring Keira Knightley and Eva Mendes, will open the fifth Rome Film Festival.

Another much-awaited title in the official selection of the Eternal City fest, which made the announcement Thursday, is the John Cameron Mitchell-helmed bereavement drama “Rabbit Hole.” Nicole Kidman, Dianne Wiest and Aaron Eckhart star.

The fest’s youth-oriented section will host the premiere of the first Italian film in 3D, Iginio Straffi’s “Winx Club 3D — Magica Avventura.”

This year the Focus section spotlights Japanese cinema and culture with tributes to Akira Kurosawa on the centenary of his birth. Rome fest, which runs Oct. 28-Nov. 5, will also include an onstage conversation between thesps Margherita Buy and Silvio Orlando.